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NF 449

Cat No.:

LIA064

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Chemical Name:

4,4^',4^'',4^'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt

Chemical Structure：

Description of NF 449

Highly selective P2X1 antagonist

Product Information of NF 449

Purity

≥90% (HPLC)

Molecular Weight

1505.06

Formula

C41H24N6Na8O29S8

CAS Number

627034-85-9

PubChem ID

91895233

Pack Size

10 mg/50 mg

InChI Key

PHCBPKWKKHYRSA-UHFFFAOYSA-F

Smiles

[Na⁺].[Na⁺].[Na⁺].[Na⁺].[Na⁺].[Na⁺].[Na⁺].[Na⁺].[O-]S(=O)(=O)C1=CC=C(NC(=O)C2=CC(=CC(NC(=O)NC3=CC(=CC(=C3)C(=O)NC3=CC=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)C(=O)NC3=CC=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C2)C(=O)NC2=CC=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)C(=C1)S([O-])(=O)=O

Biological Activity

NF 449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 (IC₅₀ values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X1, rP2X1+5, rP2X2+3, rP2X3, rP2X2 and P2X4 receptors respectively). Provides antithrombotic protection in vivo. Also acts as a Gsα-selective antagonist. Also inhibits DNA-binding activity of HMGA2 (IC₅₀ = 0.43 μM).

This product is supplied with a high degree of hydration and some residual NaCl, the amount of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content and the maximum solubility threshold to use in dilution calculations.

Storage

Store at room temperature.

For research use only, not intended for any clinical use.